A little less guesswork.

Treatments

Find a product first, then check its exact formulation and calculation status.

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Hikari

Ich-X

Select the exact Ich-X bottle: aquarium and pond strengths differ

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Hikari

Prazipro

Hikari / Aquarium Solutions PraziPro ready-to-use liquid

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Deferred

Generic chemical — brand unspecified

Hydrogen Peroxide (H2O2) 3%

Liquid aquarium product

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Seachem

Seachem Cupramine

Cupramine — choose freshwater or marine fish treatment

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API

API Melafix

API Melafix standard freshwater bottle — not Marine Melafix — US label directions

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API

API Pimafix

API Pimafix standard aquarium liquid — US label directions

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Ultralife

Ultralife Blue-Green Slime Stain Remover

Ultralife Blue-Green Slime Stain Remover — included 0.625 cc level spoon

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eSHa

eSHa Hexamita

eSHa HEXAMITA — standard freshwater three-day course

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eSHa

eSHa GASTROPEX

eSHa GASTROPEX — standard freshwater snail-treatment course

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eSHa

eSHa PROTALON 707 (bottles A + B)

PROTALON 707 — two-bottle A/B version, not 7.0.7 or 727

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Arithmetic only

Salt

Aquarium salt — concentration arithmetic

Grams of salt per litre, chosen independently

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Jump to a section
  1. Category guidance
  2. The Importance of Net Volume
  3. Supported Products
  4. Medication Comparison & Case Studies
  5. The Ultimate Guide to Aquarium Medications
  6. Common Dosing Mistakes

Category guidance

Earlier category notes are preserved below and await a full source review. Only the source-checked entries above can return a dose.

Treating fish disease requires precision. Overdosing can be toxic to the fish you are trying to save, while underdosing can lead to drug-resistant parasites.

The Importance of Net Volume

Medications are the #1 reason to use a Net Water Volume calculator. Many medications (like Copper-based treatments) have a very narrow safety margin. Dosing for a 20-gallon tank that only has 16 gallons of actual water can be fatal.

🚀 Calculate Your Dosage Now

Supported Products

Medication Comparison & Case Studies

Deciding which treatment will save your fish? Explore our technical comparisons and species-specific treatment guides.

Ich-X vs. Cupramine → Prazipro vs. ParaClean → Melafix vs. StressGuard → eSHa 2000 vs. Exit → eSHa ndx vs. Prazipro → Fin Rot Recovery Guide → Treating Flukes with gdex → Post-Treatment Cleanup →

The Ultimate Guide to Aquarium Medications

Watching your favorite fish struggle with disease is one of the most stressful parts of being an aquarist. Whether it's the white spots of Ich, the "cotton wool" look of fungal infections, or the clamped fins of internal parasites, the pressure to act fast is intense. However, successful treatment is as much about patience and precision as it is about the medicine itself.

The Golden Rule: Diagnose Before Dosing

It's tempting to reach for a "broad spectrum" treatment the moment you see a fish acting oddly. But many medications are specialized. Using a parasite treatment for a bacterial infection won't just fail to help—it will stress your fish further and potentially damage your biological filter. Spend the time to properly identify the symptoms before opening a bottle.

Why a Quarantine Tank Changes Everything

If you can, always treat in a separate quarantine tank. This is critical for several reasons:

  • Efficiency: It’s much cheaper to dose a 10-gallon hospital tank than a 125-gallon display tank.
  • Safety: Many medications are toxic to invertebrates (snails/shrimp) or sensitive plants. A hospital tank protects your main scape.
  • Focus: It allows you to monitor the sick fish closely and ensure they are actually eating the medicated food or receiving the full benefit of the water treatment.

Managing the "Safety Margin"

In the world of aquarium meds, the difference between a cure and a poison is often just a few milliliters. This is particularly true for Copper (used for velvet and Ich) and Formaldehyde (found in many Ich treatments). These chemicals have a narrow "therapeutic window." If you dose for your tank's nominal size (e.g., 20 gallons) but your rocks and substrate mean you only have 15 gallons of water, you are dangerously close to an overdose.

Potential Dangers and Side Effects

Most medications are oxygen-depleting. When treating a tank, it is vital to increase aeration. Aim your powerheads at the surface or add an air stone. If your fish are gasping at the surface during treatment, it's often not the disease—it's the medicine's effect on the oxygen levels.

Post-Treatment Care

Once the treatment course is finished, you need to remove the remaining medication. A large (50%) water change followed by fresh activated carbon in your filter for 48 hours is the standard method to "clear" the water. Don't forget to monitor your ammonia levels closely for a week, as some medications can temporarily stall your nitrogen cycle.

Common Dosing Mistakes

Mistake #1: Leaving Carbon in the Filter.

Activated carbon will remove most medications from the water before they can work. Always remove carbon, Purigen, or other chemical media before starting treatment.

Mistake #2: Stopping Treatment Early.

Even if the fish look better, many parasites have life cycles that require multiple doses. Always finish the full course as calculated.

Treating a sick fish?

Use our precision calculator to find the exact dose for your tank's net volume.

Go to Dosage Calculator

Written by Richard James

Aquarist, author, and creator of ShrimpKeeper.co.uk. Helping hobbyists achieve professional results through precision dosing.

View My YouTube Channel & Books →